Ces radiol. 2009, 63(2):122-128

Intracranial bleeding as complication of peripheral local thrombolysis and subsequent anticoagulation treatmentCase report

Antonín Krajina¹, Vendelín Chovanec¹, Radovan Malý², Miroslav Lojík¹, Jan Raupach, Ivo Šteiner³, Iva Hrubá², Ondřej Renc¹, Svatopluk Řehák⁴

¹ Radiologická klinika LF a FN Hradec Králové

² I. interní klinika LF a FN Hradec Králové

³ Fingerlandův ústav patologie LF a FN Hradec Králové

⁴ Neurochirurgická klinika LF a FN Hradec Králové

Intracranial hemorrhage is the most dreaded risk of thrombolytic therapy because of the high mortality and disability rates associated with this complication. Although systemic fibrinolysis after thrombolysis is responsible for hemorrhagic complications, many factors are implicated in predisposition to cerebral hemorrhage such as old age, uncontrolled or chronic hypertension, history of cardiac disease, hyperglycemia, patients with small body mass, previous stroke, longer therapeutic treatment window, higher thrombolytic dose. Authors present five cases of the intracranial bleeding. Two of them were patients with malignant disease which was not diagnosed in one of them, one patient with chronic renal insufficiency suffered from hemorrhage due to anticoagulation overdose, and one patient had acute subarachnoid hemorrhage from partially thrombosed calcified saccular aneurysm. There was no single cause found of multilocal intracerebral and intracerebellar hemorrhages in the last patient.

Keywords: complications, thrombolysis, thrombosis

Accepted: April 15, 2009; Published: June 1, 2009  Show citation