Ces radiol. 2014, 68(1):69-73

Evaluation of T2 lesions at baseline brain MRI as a prognostic marker in prediction the conversion of CIS to CDMSOriginal article

Monika Daňová¹, Eleonóra Klímová², Rudolf Gaško³

¹ ProMagnet s.r.o, pracovisko magnetickej rezonancie FNsP J. A. Reimana, Prešov

² Klinika neurológie FZO Prešovskej univerzity a FNsP J. A. Reimana, Prešov

³ Geriatrické centrum sv. Lukáša, Košice

Aim: Clinically isolated syndrome (Clinically Isolated Syndrome, CIS) can be the first manifestation of multiple sclerosis (MS). As a potential prognostic marker for "Identify" CIS patients with high risk of conversion to clinically Definited MS (CDMS, Poser 1983) is considered the number of T2 hypersignal brain lesions in first MR examination of the CIS patient. The aim of the study was to verify the importance of T2 hypersignal brain lesions in the first MR examination of the patient at the time of the CIS as a potential prognostic marker for the development of SM in own group of patients.

Method: retrospective evaluation of MR findings of 76 patients at the time of the CIS for the period from 06/2005 to 12/2012. All CIS patients had clinical and radiographic follow-up for at least two years. Determined parameters: gender, age of the patient at the time of the CIS, the CIS clinical picture, the number of T2 lesions on initial MRI examination.

Results: The study comprised 76 patients with a mean age at the time of CIS 34.12 ± 8.55 years. Women dominated in the set (60). To CDMS passed 31 patients (46.27%). Logrank test (p = 0.0046) comparing survival curves, the method of Cox proportional hazards model, as well as multivariate regression analysis (p = 0.0538) confirmed in our study that a higher number of T2 lesions at baseline MRI, poses a high risk of early transition CIS to CDMS.


Conclucion: Higher number of hypersignal T2 lesions on initial MR examination after CIS in our group meant a higher risk of conversion CIS to CDMS. As another possible risk factor predictive of conversion of CIS to CDMS was in accordance with literature multifocal nature of the CIS. Without statistical significance at the endpoints was the age and gender of patients at the time of the CIS.

Keywords: clinically isolated syndrome, clinically definite MS, magnetic resonance imaging, multiple sclerosis, prognostic marker

Accepted: February 15, 2014; Published: March 1, 2014  Show citation