Ces radiol. 2020, 74(2):79-84 | DOI: 10.55095/CesRadiol2020/015
Ethanol sclerotherapy of peripheral venous malformationsOriginal article
- 1 Radiologická klinika LF a FN, Olomouc
- 2 II. chirurgická klinika LF a FN, Olomouc
- 3 Oddělení plastické chirurgie FN, Olomouc
- 4 Ústav lékařské biofyziky LF UP, Olomouc
Purpose: Venous malformation is the most common type of congenital vascular malformation with an incidence of 1 to 2 in 10,000 and a prevalence of 1%. Lesions with symptoms such as pain, cosmetic problems or functional limitation are indicated for treatment. Ethanol sclerotherapy is now the treatment of choice for venous malformations. The aim of this study was to evaluate clinical outcome of venous malformation's ethanol sclerotherapy.
Methods: In total 85 patients (28 of males, mean age 30.4 years) were treated from January 2006 to December 2019 for peripheral venous malformation by ethanol sclerotherapy. Patients were treated by 96% ethanol in amount 2-25 ml per session. Sclerotherapy was performed in 1 to 23 sessions (mean 2.8 sessions per patient, median sessions per patient).
Results: The treatment was effective in 87% of patients. In the statistical analysis, there was a significant relationship between venous malformation type and result (Fisher exact test; p = 0.001), but no significant relationship between venous malformation type and number of sessions in patients with good result of sclerotherapy (Fisher exact test; p = 0.259). Of the 241 sessions performed 5.4% complications (9 minor - 3.7% and 4 major - 1.7%) occurred.
Conclusion: Ethanol sclerotherapy of peripheral venous malformation is highly effective and it has acceptable risk of complications.
Keywords: venous malformations, sclerotherapy, ethanol
Grants and funding:
Práce byla podpořena grantem MZ ČR - RVO (FNOL 0098892), RVO (LF UP 61989592), IGA_LF_2020_012.
Accepted: April 6, 2020; Published: June 1, 2020 Show citation
References
- Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg 1982; 69: 412-422.
Go to original source...
Go to PubMed...
- Vikkula M, Boon LM, Mulliken JB. Molecular genetics of vascular malformations. Matrix Biol 2001; 20: 327-335.
Go to original source...
Go to PubMed...
- Eifert S, Villavicencio JL, Kao TC, et al. Prevalence of deep venous anomalies in congenital vascular malformations of venous predominance. J Vasc Surg 2000; 31: 462-471.
Go to original source...
- Cox JA, Bartlett E, Lee EI. Vascular malformations: a review. Semin Plast Surg 2014; 28: 58-63.
Go to original source...
Go to PubMed...
- Puig S, Aref H, Chigot V, Bonin B, Brunelle F. Classification of venous malformations in children and implications for sclerotherapy. Pediatr Radiol 2003; 33: 99-103.
Go to original source...
Go to PubMed...
- Yun WS, Kim YW, Lee KB, Kim DI, Park KB, Kim KH, Do YS, Lee BB. Predictors of response to percutaneous ethanol sclerotherapy (PES) in patients with venous malformations: analysis of patient self-assessment and imaging. J Vasc Surg 2009; 50: 581-589.
Go to original source...
Go to PubMed...
- Černá M, Köcher M, Justová E, Zálešák B, Utíkal P, Kozák J, Dráč P, Thomas RP. Léčba periferních žilních malformací absolutním etanolem. Ces Radiol 2009; 63: 133-137.
- Yakes WF, Hass DK, Parker SH, Gibson MD, Hopper KD, Mulligan JS, Pevsner PH, Johns JC Jr., Carter TE. Symptomatic vascular malformation: ethanol embolotherapy. Radiology 1989; 170: 1059-1066.
Go to original source...
Go to PubMed...
- Yakes WY. Diagnostika a léčba nízkoprůtokových veno-lymfatických cévních malformací. Čes Radiol 2008; 62: 131-145.
- Jin Y, Lin X, Chen H, et al. Auricular arteriovenous malformations: potential success of superselective ethanol embolotherapy. J Vasc Interv Radiol 2009; 20: 736-743.
Go to original source...
Go to PubMed...
- Albanese G, Kondo KL. Pharmacology of sclerotherapy. Semin Intervent Radiol 2010; 27: 391-399.
Go to original source...
Go to PubMed...
- Mulligan PR, Prajapati HJ, Martin LG, Patel TH. Vascular anomalies: classification, imaging characteristics and implications for interventional radiology treatment approaches. Br J Radiol 2014; 87: 20130392.
Go to original source...
Go to PubMed...
- Behravesh S, Yakes W, Gupta N, et al. Venous malformations: clinical diagnosis and treatment. Cardiovasc Diagn Ther 2016; 6: 557-569.
Go to original source...
Go to PubMed...
- van der Vleuten CJ, Kater A, Wijnen MH, Schultze Kool LJ, Rovers MM. Effectiveness of sclerotherapy, surgery, and laser therapy in patients with venous malformations: a systematic review. Cardiovasc Intervent Radiol 2014; 37: 977-989.
Go to original source...
Go to PubMed...
- Nakamura M, Osuga K, Maeda N, et al. Percutaneous sclerotherapy for venous malformations in the extremities: clinical outcomes and predictors of patient satisfaction. Springerplus 2014; 3: 520.
Go to original source...
Go to PubMed...
- Yakes WF, Luethke JM, Parker SH, et al. Ethanol embolization of vascular malformations. Radiographics 1990; 10: 787-796.
Go to original source...
Go to PubMed...
- Berenguer B, Burrows PE, Zurakowski D, Mulliken JB. Sclerotherapy of craniofacial venous malformations: complications and results. Plast Reconstr Surg 1999; 104: 1-15.
Go to original source...
- Lee BB, Do YS, Byun HS, Choo IW, Kim DI, Huh SH. Advanced management of venous malformation with ethanol sclerotherapy: mid-term results. J Vasc Surg 2003; 37: 533-538.
Go to original source...
Go to PubMed...
- Horbach SE, Lokhorst MM, Saeed P, de Goüyon Matignon de Pontouraude CM, Rothová A, van der Horst CM. Sclerotherapy for low-flow vascular malformations of the head and neck: A systematic review of sclerosing agents. J Plast Reconstr Aesthet Surg 2016; 69: 295-304.
Go to original source...
Go to PubMed...
- Khaitovich B, Kalderon E, Komisar O, Eifer M, Raskin D, Rimon U. Venous malformations, sclerotherapy: outcomes, patient satisfaction and predictors of treatment success. Cardiovasc Intervent Radiol 2019; 42: 1695-1701.
Go to original source...
Go to PubMed...
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.