Ces radiol. 2024, 78(2):77-89 | DOI: 10.55095/CesRadiol2024/011

Positron emission tomography with the application of 18F-fluorodeoxyglucose in the differential diagnostics of neurodegenerative diseases with the cognitive impairment and role of amyloid beta specific radiopharmaceutical in Alzheimer disease confirmationReview article

Jiří Ferda, Eva Ferdová
Klinika zobrazovacích metod LF UK a FN, Plzeň

18F-FDG-PET imaging in patients with neurodegenertive diseases is theoiptimal method to distinguish several types of the neurodegenerationsincluding coexisting pathologies. Individual types of diseases or groups ofdiseases exhibit specific patterns of hypometabolism distribution - inparticular, frontotemporal degeneration can be distinguished from dementiawith Léwy bodies and Alzheimer´s disease, as well as diseases characterized byspeech disorders from the group of primary progressive aphasia or diseaseswith movement disorders such as corticobasal degeneration. Additionalamyloid-beta imaging serves to confirm the amyloid beta presence within graycortical matter in Alzheimer disease.

Keywords: neurodegenerative diseases, Alzheimer disease, frontotemporaldegeneration, 18F-FDG-PET, amyloid beta PET

Published: June 1, 2024  Show citation

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Ferda J, Ferdová E. Positron emission tomography with the application of 18F-fluorodeoxyglucose in the differential diagnostics of neurodegenerative diseases with the cognitive impairment and role of amyloid beta specific radiopharmaceutical in Alzheimer disease confirmation. Ces radiol. 2024;78(2):77-89. doi: 10.55095/CesRadiol2024/011.
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