Ces radiol. 2024, 78(2):90-94 | DOI: 10.55095/CesRadiol2024/012

Structural MR imaging of the brain in patients with Alzheime´s disease/ARIA assessment - initial practical informationReview article

Martin Kynčl¹, Jakub Otáhal², Jakub Hort³, Robert Rusina⁴, Jiří Ferda⁵

¹ Klinika zobrazovacích metod 2. LF UK a FN Motol, Praha

² Ústav patologické fyziologie, 2. LF UK, Praha

³ Neurologická klinika 2. LF UK a FN Motol, Praha

⁴ Neurologická klinika 3. LF UK a FTN, Praha

⁵ Klinika zobrazovacích metod LF UK, Plzeň

The following text is intended primarily for radiologists andneuroradiologists and serves as an introduction to the use of MR imaging inthe diagnostic process and monitoring of biological treatment of Alzheimer?sdisease. With the rapid development of therapeutic options and the expectedavailability of treatment with monoclonal antibodies against beta amyloid inpatients with Alzheimer´s disease, we will soon face demands for standardizedimaging in support of diagnosis and safety monitoring of this treatment.Neurodegenerative diseases leading to the development of dementia are aserious group of diseases with an increasing prevalence worldwide. There arecurrently an estimated 180,000 patients with dementia in the Czech Republic,of whom 60-70% are Alzheimer´s disease (1). This condition and the expectedfurther increase in the number of patients due to the ageing of the populationnecessarily entails increased healthcare costs and a critical burden on theentire healthcare system, including diagnosis and the use of follow-upmodalities. Knowledge and logistical readiness is the only way to avoidoverwhelming the healthcare system while meeting the demands of both medicalprofessionals and patients.

Keywords: Alzheimer disease, biological therapy, magnetic resonance imaging

Published: June 1, 2024  Show citation