Ces radiol. 2016, 70(3):129-137 | DOI: 10.55095/CesRadiol2016/020

¹⁸F-FDG-PET/MRI in children with Hodgkin's diseaseOriginal article

Jiří Ferda, Eva Ferdová, Jan Baxa

Klinika zobrazovacích metod LF UK a FN, Plzeň

Aim: To evaluate the feasibility of the staging and restaging imaging of children suffering from Hodgkin's disease ¹⁸F-FDG-PET/MRI.

Method: In 12 children in the age 8 to 15 years with proven diagnosis of Hodgkin's disease, 26 procedures were performed using the integrated PET/MRI. The dosing of 2 MBq of ¹⁸F-FDG per kilogram of body weight was used. The whole-body or whole trunk imaging was used using T1 VIBE Dixon two-point, TIRM T2 STIR and DWI after application of gadolinium contrast agent. The data acquisition lasts 4 minutes in each position. All examinations were performed without need of the general anaesthesia. The imaging evaluation was driven in the intentions of the WHO Hodgkin's disease staging or during interim examinations using the Deauville score system.

Results: All examinations were evaluated as adequate from the point of view of diagnostic quality of examination, the applied radiopharmaceutical activity varied between 45 to 151 MBq. The coupled staging and interim examinations were performed in 9 children, in three children classified as score 4 or 5 according Deauville schema, the additional follow-up study was added to complete the therapy response imaging.

Conclusion: Hybrid imaging ¹⁸F-FDG-PET/MRI with low ¹⁸F-FDG-dosing reaches the optimal diagnostic quality in the assessment of the staging and also restaging of the Hodgkin's disease, when the attitude with lower ¹⁸F-FDG-dosing enables the lowering the total radiation dose burden to the ill children.

Keywords: Hodgkin's disease, ¹⁸F-fluorodeoxyglucose, PET, MRI

Grants and funding:

Podpořeno projektem Ministerstva zdravotnictví ČR Koncepční rozvoj výzkumné instituce 00669806 - FN Plzeň a Programem rozvoje vědních oborů Karlovy Univerzity (projekt P36).

Accepted: September 15, 2016; Published: September 1, 2016  Show citation