Ces radiol. 2014, 68(1):16-21

Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) in multiple myeloma diagnosisOriginal article

Jana Sedláková1, Miloš Keřkovský1, Tomáš Pavlík2, Marek Mechl1
1 Radiologická klinika FN MU, Brno
2 Institut biostatistiky a analýz LF MU, Brno

Aim: Diffusion-weighted imaging is a useful sequence, which helps to determine the nature of pathology found on T1 and T2 weighted images in examination of oncologic patients. We compared T1 weighted and STIR images with diffusion weigted whole body imaging (DWIBS). We also tested possibility of DWIBS quantification.

Method: Data from studies made between May 2007 and October 2012 with the whole-body protocol on a device Philips Achieva 1,5T were analysed retrospectively and 106 patients with multiple myeloma or monoclonal gamapathy of unknown significance (MGUS) were included.
We compared the number of lesions found on T1 weighted and STIR images and DWIBS. Patients were then divided into two groups - the first group of patients with negative findings on T1-weighted and STIR images, and the other with a no pathological signal on these sequences. In the first group we compared signal intensity from the right hip and fifth lumbar vertebra to the signal intensity of kidney, spleen and liver, in the second group a signal intensity of leasions to signal intensity of these organs.
An arithmetic mean, standard deviation, median, minimum, maximum and McNemar and Wilcoxon tests were used to identify characteristics and differences between T1 weighted and STIR images and DWIBS. Mann-Whitney test was used to identify differences of signal ratio in DWIBS between reference group and group with lesions.

Results: The analysis of T1 wighted imaging + STIR and DWIBS examinations showed that DWIBS is more sensitive (Wilcoxon test, p < 0.001). In evaluation of signal ratio to liver, kidney and spleen, there was significant difference between reference group and group with lesions on T1 weighted imaging and STIR (p < 0.001).

Conclusion: DWIBS is more sensitive than T1 weighted imaging and STIR images, one of possible ways to reach higher specificity could be comparison of the signal ratio to liver, kidney or spleen.

Keywords: magnetic resonance, whole body imaging, diffusion weighted imaging with backround body signal supression, multiple myeloma

Accepted: September 1, 2013; Published: March 1, 2014  Show citation

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Sedláková J, Keřkovský M, Pavlík T, Mechl M. Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) in multiple myeloma diagnosis. Ces radiol. 2014;68(1):16-21.
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