Ces radiol. 2017, 71(3):183-187 | DOI: 10.55095/CesRadiol2017/024

Dynamic T1-Contrast-Enhanced 3T-MRI of peritumoral white matter in differentiation between glioblastomas and metastasesOriginal article

Radek Tupý1, Jiří Ferda1, Jan Kastner1, Vladimír Přibáň2, Ondřej Hes3, Samuel Vokurka4
1 Klinika zobrazovacích metod LF UK a FN, Plzeň
2 Neurochirurgická klinika LF UK a FN, Plzeň
3 Šiklův ústav patologie LF UK a FN, Plzeň
4 Onkologická a radioterapeutická klinika LF UK a FN, Plzeň

Aim: To verify difference in peritumoral white matter nearby glioblastomas and metastatic tumors in dynamic contrast enhanced (DCE-MRI) 3T-MRI using GRE-T1 techniques.

Methods: Retrospective comparative study of adults with glioblastoma (n = 46) and brain metastases (n = 21). Conventional 3T-MRI and DCE-MRI continuously detecting 25 acquisitions of GRE-T1. The iAUC (initial area under the curve) and Ktrans (transfer constant) in peritumoral regions of the white matter were evaluated using T1 pharmacodynamic modeling software.

Results: Statistically significantly higher iAUC and Ktrans values were observed in peritumoral white matter near glioblastomas vs. metastases: 2.35 (SD 1.36) and 2.08 (SD 1.35) vs. 0.98 (SD 0.36) and 1.16 (SD 0.36), p < 0.001 and p = 0.02.

Conclusion: In comparison to Ktrans, the iAUC obtained by DCE-MRI is more suitable to assess glioblastomas. Increased iAUC nearby tumor mostly indicates glioblastoma, however, low level does not exclude it.

Keywords: brain, glioblastoma, magnetic resonance imaging, neoplasm metastasis
Grants and funding:

Podpořeno projektem institucionálního výzkumu MZ ČR 00669806 Fakultní nemocnice v Plzni a projektem výzkumu Univerzity Karlovy - projekt P36.

Accepted: September 15, 2017; Published: September 1, 2017  Show citation

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Tupý R, Ferda J, Kastner J, Přibáň V, Hes O, Vokurka S. Dynamic T1-Contrast-Enhanced 3T-MRI of peritumoral white matter in differentiation between glioblastomas and metastases. Ces radiol. 2017;71(3):183-187. doi: 10.55095/CesRadiol2017/024.
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