Ces radiol. 2020, 74(1):33-36 | DOI: 10.55095/CesRadiol2020/006

Masking of acute basal ganglia infarction in CT perfusionCase report

Miroslav Malík1, Peter Mikula1, Magdaléna Mižičková1, Dagmar Randová1, Tomáš Tvrdík1, Marek Krivošík2, Jozef Bilický1, Vladimír Javorka1
1 Rádiologická klinika LF UK, SZU a UNB, Bratislava, SR
2 II. Neurologická klinika LF UK a UNB, Bratislava, SR

Extension of ischemic stroke revascularization therapy window has lead to an increase in the utilization of CT perfusion for selecting patients who could benefit from the treatment. Outcomes from applying the technique can be influenced by various technical and pathophysiological factors that can impact the results' incorrect interpretation. One of these factors is the restoration of nonnutritive perfusion in brain tissue affected by ischemia, which can be caused due to spontaneous or therapeutic recanalization of the obliterated artery. This phenomenon is typically visible in the subacute phase after recanalization, but may also occur for up to 24 hours after the onset of clinical symptoms. Reperfusion, which is usualy characterized by higher-than-normal flow can mask ischemic lesion in CT perfusion maps and may lead to negative diagnosis. In the case report, we present a patient with acute stroke involving a large vessel occlusion and nearly normal CT perfusion appearance in basal ganglia infarction.

Keywords: CT perfusion, ischemic stroke

Accepted: January 30, 2020; Published: March 1, 2020  Show citation

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Malík M, Mikula P, Mižičková M, Randová D, Tvrdík T, Krivošík M, et al.. Masking of acute basal ganglia infarction in CT perfusion. Ces radiol. 2020;74(1):33-36. doi: 10.55095/CesRadiol2020/006.
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References

  1. Albers GW, Marks MP, Kemp S, et al. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med 2018; 378(8): 708-718. Go to original source... Go to PubMed...
  2. Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct. N Engl J Med 2018; 378(1): 11-21. Go to original source... Go to PubMed...
  3. Hunter GJ, Hamberg LM, Ponzo JA. Assessment of cerebral perfusion and arterial anatomy in hyperacute stroke with three-dimensional functional CT: early clinical results. AJNR Am J Neuroradiol 1998; 19(1): 29-37.
  4. Donahue J, Wintermark M. Perfusion CT and acute stroke imaging: foundations, applications, and literature review. J Neuroradiol 2015; 42(1): 21-29. Go to original source... Go to PubMed...
  5. Lui YW, Tang ER, Allmendinger AM, Spektor V. Evaluation of CT perfusion in the setting of cerebral ischemia: patterns and pitfalls. AJNR Am J Neuroradiol 2010; 31(9): 1552-1563. Go to original source... Go to PubMed...
  6. Abels B, Villablanca JP, Tomandl BF, Uder M, Lell MM. Acute stroke: a comparison of different CT perfusion algorithms and validation of ischaemic lesions by follow-up imaging. EurRadiol 2012; 22(12): 2559-2567. Go to original source... Go to PubMed...
  7. Marchal G, Beaudouin V, Rioux P, et al. Prolonged persistence of substantial volumes of potentially viable brain tissue after stroke: a correlative PET-CT study with voxel-based data analysis. Stroke 1996; 27: 599-606. Go to original source... Go to PubMed...
  8. Waaijer A, van der Schaaf IC, Velthuis BK, et al. Reproducibility of quantitative CT brain perfusion measurements in patients with symptomatic unilateral carotid artery stenosis. AJNR Am J Neuroradiol 2007; 28: 927-932.
  9. Nguyen TB, Lum C, Eastwood JD, et al. Hyperperfusion on perfusion computed tomography following revascularization for acute stroke. Acta Radiol 2015; 46: 610-615. Go to original source... Go to PubMed...
  10. Nagar VA, McKinney AM, Karagulle AT, Truwit CL. Reperfusion phenomenon masking acute and subacute infarcts at dynamic perfusion CT: confirmation by fusion of CT and diffusion-weighted MR images. AJR Am J Roentgenol 2009; 193(6): 1629-1638. Go to original source... Go to PubMed...
  11. Olsen TS, Lassen NA. A dynamic concept of middle cerebral artery occlusion and cerebral infarction in the acute state based on interpreting severe hyperemia as a sign of embolic migration. Stroke 1984; 15: 458-468. Go to original source... Go to PubMed...
  12. Yamauchi H, Kudoh T, Sugimoto K, et al. Pattern of collaterals, type of infarcts, and haemodynamic impairment in carotid artery occlusion. J Neurol Neurosurg Psychiatry 2004; 75: 1697-1701. Go to original source... Go to PubMed...
  13. Konstas AA, Goldmakher GV, Lee TY, Lev MH. Theoretic basis and technical implementation of CT perfusion in acute ischemic stroke. Part 1. Am J Neuroradiol 2009; 30: 662-668. Go to original source... Go to PubMed...
  14. Marco de Lucas E, Gonzalez Mandly A, Gutierrez A, et al. Computed tomography perfusion usefulness in early imaging diagnosis of herpes simplex virus encephalitis. Acta Radiol 2006; 47: 878-881. Go to original source... Go to PubMed...
  15. Shahi V, Fugate JE, Kallmes DF, Rabinstein AA. Early Basal Ganglia Hyperperfusion on CT Perfusion in Acute Ischemic Stroke: A Marker of Irreversible Damage? AJNR Am J Neuroradiol 2014; 35(9): 1688-1692. Go to original source... Go to PubMed...

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