Ces radiol. 2020, 74(4):268-274 | DOI: 10.55095/CesRadiol2020/040

Are there differences of cortical thickness or surface area between subjects after the first episode of schizophrenia and healthy controls?Original article

Ondřej Slezák^1,2, Antonín Škoch^3,4, Jan Žižka⁵, David Bayer⁶, Filip Španiel⁴, Jaroslav Tintěra^3,4, Jiří Vaňásek^1,2, Pavel Eliáš^1,2, Pavel Ryška^1,2

¹ Radiologická klinika LF UK, Hradec Králové

² Radiologická klinika FN, Hradec Králové

³ Základna radiodiagnostiky a intervenční radiologie IKEM, Praha

⁴ Národní ústav duševního zdraví, Klecany

⁵ Department of Radiology, University Hospital of Umeå, Daniel Naezéns väg, Sweden

⁶ Psychiatrická klinika FN, Hradec Králové

Purpose: To asses cerebral cortical thickness and area changes in the earliest stage of schizophrenia.

Methods: Magnetic resonance was used to prospectively compare cerebral cortex thickness and surface area between subjects after the first episode of schizophrenia (n = 15) and healthy controls (n = 19). The subjects were examined on a 3 Tesla MRI system equipped with a 64-channel head coil. Surface-based morphometry was performed on 3D T1- and T2-weighted data by using Freesurfer software package (ver. 7.1.0).

Results: No statistically significantly different clusters of cerebral cortical surface / thickness were found between both groups of subjects.

Conclusion: Contrary to the observations published by other authors including large multicentric studies, no statistically significant differences in cerebral cortical thickness or area were found in the earliest stage of schizophrenia.

Keywords: first episode of schizophrenia, cortical area, cortical thickness, magnetic resonance, surface-based morphometry

Grants and funding:

Podpořeno MZ ČR - RVO (FNHK, 00179906) a projektem číslo LO1611 za finanční podpory MŠMT v rámci programu NPU I.

Accepted: December 15, 2020; Published: December 1, 2020  Show citation