Ces radiol. 2023, 77(1):25-28 | DOI: 10.55095/CesRadiol2023/004
Embolization particles for TACEReview article
- Klinika radiologie a nukleární medicíny LF MU a FN, Brno
Transarterial chemoembolization (TACE) is one of the basic methods ofendovascular treatment of cancer. It is mainly used in hypervascularized livertumors, which are predominantly supplied with arterial blood in contrast tonormal liver parenchyma. TACE uses a combination of ischemia of the tumor andhigh local concentration of the simultaneously administered chemotherapeuticagent. The oldest agent suitable for chemoembolization is lipiodol. In thelast 25 years emerged drug eluting particles and degradable particles.Individual particles differ mainly in size, binding of the chemotherapeuticagent and degradability. Several types of particles suitable forchemoembolization are available on the market, but the superior efficacy ofany type of particle has not yet been clearly demonstrated. However, dependingon the size of the tumour, the selectivity of the arterial approach and thepatient´s condition, the choice of the correct particle size and the choice ofpermanent or degradable particles may influence the success and side effectsof treatment, while degradable particles can also be used non-selectively andin patients with risk factors.
Keywords: chemoembolization, microparticles, microsperes, doxorubicinhepatocellular carcinoma
Published: March 1, 2023 Show citation
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