Ces radiol. 2007, 61(3):275-278

X-linked Adrenoleukodystrophy: MR evaluation with "Loes Score"Original article

Zdeněk Seidl1, Manuela Vaněčková1, TomášViták1, Mirek Kron1, Lenka Dvořáková2, Jiří Zeman2,3
1 Radiodiagnostická klinika 1. LF UK a VFN, Praha
2 Ústav dědičných poruch metabolismu 1. LF UK a VFN, Praha
3 Klinika dětského a dorostového lékařství 1. LF UK a VFN, Praha

Aim: The introduction of the "Loes score" into clinical practice is needed to ensure compliance with new medical treatment criteria. Experience of "Loes Score" evaluation in patients with X-linked adrenoleukodystrophy (X-ADL) is presented. This evaluation determines the extent of brain damage in MRI and is a significant criterion for the indication of bone transplantation.

Method: MR was performed on 9 patients using the following protocol: T1W, T2W and FLAIR in the transversal plane.

Results: The median of the Loes score was 2.5 (between 0.5 and 7).

Conclusion: The introduction of the Loes score into clinical practice is needed to ensure compliance with new medical treatment criteria. We have demonstrated how to use this score and pinpointed some of the problems associated with the interpretation of MRI findings.

Keywords: magnetic resonance imaging, "Loes score", x-linked adrenoleukodystrophy
Grants and funding:

Práce vznikala s podporou výzkumného záměru MZO/00064165 a MSMOO21620849.

Accepted: October 1, 2007; Published: September 1, 2007  Show citation

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Seidl Z, Vaněčková M, TomášViták, Kron M, Dvořáková L, Zeman J. X-linked Adrenoleukodystrophy: MR evaluation with "Loes Score". Ces radiol. 2007;61(3):275-278.
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