Ces radiol. 2011, 65(1):41-50

Hybrid imaging PET/CT with the application of 18F-Fluorthymidine (18F-FLT) in malignant head and neck tumorsOriginal article

Jiří Ferda1, Eva Ferdová1, Martin Vít Matějka2, Jindřich Fínek2
1 Klinika zobrazovacích metod LF UK a FN, Plzeň
2 Oddělení radioterapie a onkologie FN, Plzeň

Aim: To introduce the new possibilities of the imaging in patients with malignant head and neck tumours using 18F-FLT-PET/CT and its impact tho patient management.


Material and method. 15 patients with head and neck malignacy underwent 18F-FLT-PET/CT during radiotherapy. All examinations were performed after intravenous administration of 18F-FLT in the dose of 1.8 MBq/kg and after 60 min accumulation phase. The imaging included full-diagnostic MDCT. The impact on the patient management was evaluated from the point of view of further radiotherapy planning.

Results: In three patients, the residual proliferative tumorous tissue populatin was confirmed. The finding induced escalation and focusation of the radiotherapy into the sites of proliferation.

Conclusion: The radiotherapy effect could be observed with the use of 18F-FLT-PET/CT and findings are suitable for radiation dose escalation planning.

Keywords: head and neck tumors, squamous-cell carcinoma, PET/CT, fluorthymidine, escalated radiotherapy

Accepted: January 15, 2011; Published: March 1, 2011  Show citation

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Ferda J, Ferdová E, Matějka MV, Fínek J. Hybrid imaging PET/CT with the application of 18F-Fluorthymidine (18F-FLT) in malignant head and neck tumors. Ces radiol. 2011;65(1):41-50.
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