Ces radiol. 2015, 69(1):27-31 | DOI: 10.55095/CesRadiol2015/003

Presurgical N-staging in breast carcinoma with ¹⁸F-FDG-PET/CTOriginal article

Eva Ferdová¹, Jiří Ferda¹, Alexander Malán¹, Ilona Zedníková², Andrea Ňaršanská², Ondřej Hes³

¹ Klinika zobrazovacích metod LF UK a FN, Plzeň

² Chirurgická klinika LF UK a FN, Plzeň

³ Šiklův ústav patologické anatomie LF UK a FN, Plzeň

Aim: to evaluate the possibilities of the N-staging assesment of the breast carcinoma using ¹⁸F-FDG-PET/CT.

Method: In 26 women examined before surgery using ¹⁸F-FDG-PET/CT, the performance was compared when the three-ring PET system was used (15 women) and four-ring PET system with image reconstruction using time-of-flight and point spread function even with the radiopharmaceuticals dose reduction to 2.5 MBq/kg from 4 MBq/kg.

Results: The sensitivity to detect axillary lmph nodes metastases reached 85%, specificity of 65% in the whole sample, in patients examined by the system enabling the reconstruction time-of-flight and point spread function, the sensitivity was improved significantly to 100% with specificity of 85%.

Conclusion: The reconstructions of the PET images with time-of-flight and point spread function were enabling the improvement of the diagnostic performance in N-staging of breast carcinoma even the dose of radiopharmaceutical was descreased to 2.5 Mbq/kg.

Keywords: PET/CT, FDG, breast cancer, N-staging

Grants and funding:

Podpořeno projektem Ministerstva zdravotnictví ČR Koncepční rozvoj výzkumné instituce 00669806 - FN Plzeň a Programem rozvoje vědních oborů Karlovy Univerzity (projekt P36) a grantem IGA 96-37.

Accepted: January 15, 2015; Published: March 1, 2015  Show citation