Ces radiol. 2018, 72(3):177-187 | DOI: 10.55095/CesRadiol2018/026

Central nervous system involvement in acute leukemiaOriginal article

Hana Petrášová¹, Miloš Keřkovský¹, Radka Šlaisová¹, Zuzana Šustková², Tereza Andrašinová³

¹ Klinika radiologie a nukleární medicíny LF MU a FN Brno

² Interní hematologická a onkologická klinika FN Brno

³ Neurologická klinika LF MU a FN Brno

Aim: The aim of this study was to describe the spectrum of MR findings in patients with a history of acute leukemia who recently had a positive cytological finding in cerebrospinal fluid.

Method: Retrospective analysis of imaging examinations (MRI of the brain and/or spinal cord) in patients with leukemic CNS infiltration confirmed by analysis of the cerebrospinal fluid.

Results: In the time period of the last 11 years (2006-2017), eight patients with CNS infiltration by leukemic cells were diagnosed in our hospital. Six of these patients (2 females, 4 males, age range 26 to 71 years) underwent a MR examination of the brain and/or spinal cord (depending on the clinical picture), revealing abnormal findings in 4 cases.
Pachymeningeal enhancement (n = 0), leptomeningeal enhancement (n = 2), cranial nerve enhancement (n = 0), parenchymal brain involvement (n = 4), parenchymal spinal cord involvement (n = 1).

Conclusion: MRI examination of the spinal cord and/or brain showed an abnormal findings in 4 of 6 patients with CNS leukemia.

Keywords: CNS, CSF, leukemia, leukemic meningitis

Grants and funding:

Práce byla podpořena projektem specifického výzkumu Lékařské fakulty Masarykovy univerzity MUNI/A/1208/2016.

Accepted: August 15, 2018; Published: September 1, 2018  Show citation