Ces radiol. 2025, 79(1):41-44 | DOI: 10.55095/CesRadiol2025/005

Congenital mesoblastic nephroma - cellular variantCase report

Kateřina Jendrišáková, Zdeňka Ráčilová, Ivana Červinková

Oddělení dětské radiologie, Klinika radiologie a nukleární medicíny LF MU a FN, Brno

Mesoblastic nephroma is the most common renal tumor in the neonatal period and infants less than three months old. There are three subtypes of mesoblastic nephroma: classic, cellular and mixed. It is mostly a benign tumor, although the cellular subtype may show signs of aggressive behavior. This case report describes a patient with a cellular subtype with heterogeneous structure, cystic degeneration and, according to histology, infiltration of the surrounding adipose tissue and perineural propagation. Cytogenetics also revealed the ETV6-NTRK3 gene fusion, which is typical for the cellular variant and allows its differentiation from the classic variant. The treatment of choice is surgical resection, adjuvant chemotherapy is advised for higher stages of cellular variant. Differential diagnosis from Wilms tumor is problematic, there are characteristics relatively typical for individual tumors, but absolute distinction is unfortunately not always possible by diagnostic imaging and the diagnosis can only be established by histological examination.

Keywords: cellular mesoblastic nephroma, congenital mesoblastic nephroma, CMN, neonate tumor, kidney tumor.

Accepted: January 31, 2025; Published: April 22, 2025  Show citation