Ces radiol. 2007, 61(1):68-73

Assessment of bone mineral density in hemodialysed patientsOriginal article

Kristýna Ohlídalová¹, Jan Mareš², Jiří Ferda¹, Hynek Mírka¹, Boris Kreuzberg¹

¹ Radiodiagnostická klinika LF UK a FN, Plzeň-Lochotín

² I. interní klinika LF UK a FN, Plzeň-Lochotín

Aim: To assess the bone mineral density in a group of hemodialysed patients and compare it with serum levels of intact parathormone, calcium, phosphorus and to evaluate its relation with coronary calcium score and duration of hemodialysis.

Method: The study was performed in a group of 72 hemodialysed patients. All patients underwent quantitative computed tomography examination of bone mineral density which was measured at the levels of lumbar vertebral bodies L1-3. Detected values of T-score were correlated with levels of intact parathormone, calcium, phosphorus, duration of hemodialysis, and calcium score. Data acquisition including assessment of coronary calcium score was performed immediately after bone mineral density anylysis.

Results: No statistically significant dependency was found between increased (p1) or decreased (p2) bone mineral density and calcium score (p1 = 0,284; p2 = 0,621), levels of phosphorus (p1 = 0,507; p2 = 0,752), calcium (p1 = 0,8; p2 = 0,895), calciumphosphorus product (p1 = 0,158; p2 = 0,731), intact parathormone (p1 = 0,906; p2 = 0,957), duration of hemodialysis (p1 = 0,160; p2 = 0,675), and presence of diabetes mellitus (p = 0,222).

Conclusion: The development of the renal osteodystrophy depends on multiple factors. No statistically significant dependency of bone mineral density was found in relation to the parameters evaluated.

Keywords: phosphorus, coronary calcium scoring, hemodialysis, bone mineral analysis, parathormone

Grants and funding:

Studie byla provedena za podpory výzkumného záměru č. MSM 0021620819.

Accepted: December 15, 2006; Published: March 1, 2007  Show citation