Ces radiol. 2007, 61(4):380-386
Calcium scoring in haemodialysed patientsOriginal article
- 1 Radiodiagnostická klinika LF UK a FN, Plzeň-Lochotín
- 2 I. interní klinika FN, Plzeň-Lochotín
Aim: To perform calcium scoring (CAS) in a group of patients with chronic renal failure treated by hemodialysis. CAS is playing an important role in screening for coronary artery calcification. The result of CAS is Agatston score, an independent factor for increased cardiovascular mortality rate.
Method: Our study was performed in a group of 72 hemodialysis patients. All patients underwent computed tomography examination of the bone mineral density and calcium scoring. Detected values of Z-score and CAS were correlated with levels of intact parathormone (iPTH), calcium (Ca), phosphorus (P), calciumphosphorus product (CaxP), duration of hemodialysis, vitamin D treatment and history of diabetes mellitus. The tests were repeated after one year and the results were compared.
Results: Correlation between increased CAS (very high risk of cardiovascular mortality) and increased levels of phosphorus (p = 0.01) and increased calciumphosphorus product (p = 0.004) was statistically significant. There was a significant increase of CAS within one year (p = 0.0001).
Conclusion: Patients with chronic renal failure and disorders of calcium-phosphate metabolism are threatened by ectopic calcification deposits. Calcium scoring is an independent factor for assessment of increased cardiovascular mortality rate.
Keywords: calcium scoring - haemodialysis - chronic renal failure
Grants and funding:
Práce byla podpořena výzkumným záměrem č. MSM 0021620819.
Accepted: August 10, 2007; Published: December 1, 2007 Show citation
References
- Raggi P, Bommer J, Chertow GM. Valvular calcification in hemodialysis patients randomized to calcium-based phosphorus binders or sevelamer. J Heart Valve Dis 2004; 13(1): 134-141.
- Ferda J. CT angiografie. Praha: Galén 2004; 38-39.
- Lau G, Ridley L, Schieb M. Coronary artery stenoses: Detection with calcium scoring, CT angiography, and both methods combined. Radiology 2005; 235: 415-422.
Go to original source...
Go to PubMed...
- Gallieni M, Cucciniello E, D'Amaro E, et al. Calcium, phoshate, and PTH levels in the hemodialysis population: a multicenter study. J Nephrol 2002; 15(2): 165-170.
- Melamed ML, Eustace JA, Plantinga L. Changes in serum calcium, phosphate, and PTH and the risk of death in incident dialysis patients: a longitudinal study. Kidney Int 2006; 70(2): 351-357.
Go to original source...
Go to PubMed...
- Zittermann A. Vitamin D and disease prevention with special reference to cardiovascular disease. Prog Biophys Mol Biol 2006; 92(1): 39-48.
Go to original source...
Go to PubMed...
- Iwasaki Y, Yamato H, Nii-Kono T, et al. Insufficiency of PTH action on bone in uremia. Kidney Int 2006; 102(Suppl): S34-S36.
Go to original source...
Go to PubMed...
- Cozzolino M, Gallieni M, Brancaccio D. Vascular calcification in uremic conditions: new insights into pathogenesis. Semin Nephrol. 2006; 26(1): 33-37.
Go to original source...
Go to PubMed...
- Coen G, Ballanti P, Balducci A. Renal osteodystrophy: alpha-Heremans Schmid glycoprotein/fetuin-A, matrix GLA protein serum levels, and bone histomorphometry. Am J Kidney Dis 2006; 48(1): 106-113.
Go to original source...
Go to PubMed...
- Mohler E, Gannon F, Reynolds C. Bone formation and inflammation in cardiac valves. Circulation 2001; 103: 1522-1528.
Go to original source...
Go to PubMed...
- Coen G, Manni M, Mantella D, Splendiani G. Can cardiovascular calcifications be prevented in chronic kidney disease? G Ital Nefrol 2006; 23(Suppl 34): S21-S25.
- Galassi A, Spiegel DM, Bellasi A, et al. Accelerated vascular calcification and relative hypoparathyroidism in incident haemodialysis diabetic patients receiving calcium binders. Nephrol Dial Transplant 2006; 21: 3215-3222.
Go to original source...
Go to PubMed...
- Merjanian R, Budoff M, Adler S. Coronary artery, aortic wall, and valvular calcification in nondialyzed individuals with type 2 diabetes and renal disease. Kidney Int 2003; 64(1): 263-271.
Go to original source...
Go to PubMed...
- Shoji T, Nishizawa Y. Effects of vitamin D on the cardiovascular system. Clin Calcium 2006; 16(7): 23-30.
- Allison M, Cheung P, Criqui M. Mitral and aorticannular calcification are highly associated with systemic calcified atherosclerosis. Circulation 2006; 113: 861-866.
Go to original source...
Go to PubMed...
- Haydar Ali A., Hujairi Nabil M. A., Covic A. Coronary artery calcification is related to coronary atherosclerosis in chronic renal disease patients: a study comparing EBCT-generated coronary artery calcium scores and coronary angiography. Nephrol Dial Transplant (2004) 19: 2307-2312.
Go to original source...
Go to PubMed...
- Mehrotra R. Disordered mineral metabolism and vascular calcification in nondialyzed chronic kidney disease patients. J Ren Nutr 2006; 16(2): 100-118.
Go to original source...
Go to PubMed...
- Raggi P, Bellasi A. Clinical assessment of vascular calcification. Adv Chronic Kidney Dis 2007; 14(1): 37-43.
Go to original source...
Go to PubMed...
- Raggi P, Boulay A, Chasan-Taber S. Cardiac calcification in adult hemodialysis patients a link between end-stage renal disease and cardiovascular disease? JACC 2002; 39: 695-701.
Go to original source...
Go to PubMed...
- Shemesh J, et al. Tracking Coronary Calcification by Using Dual-Section Spiral CT: A 3-Year Follow-up. Radiology 2000; 217: 461-465.
Go to original source...
Go to PubMed...
- Jung H, et al. Inflammation, mineral metabolism and progressive coronary artery calcification in patients on haemodialysis, Nephrol Dial Transplant 2006; 21(7): 1915-1920.
Go to original source...
Go to PubMed...
- Shaw L, Raggi P, Schisterman E. Prognostic value of cardiac risk factors and coronary artery calcium screening for all-cause mortality. Radiology 2003; 228: 826-833.
Go to original source...
Go to PubMed...
- Pecovnik B, et al. Bone mineral density in patients beginning hemodialysis treatment, Am J Nephrol 2002; 22(1): 14-17.
Go to original source...
Go to PubMed...
- Russo D, et al. Progression of coronary artery calcification in predialysis patients. Am J Nephrol 2007; 27(2): 152-158.
Go to original source...
Go to PubMed...
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.