Ces radiol. 2008, 62(4):329-333

Effect of intravascular iodinated contrast media on residual renal function in hemodialysed patients - a prospective studyOriginal article

Radim Janoušek¹, Antonín Krajina², Ondřej Renc², Jan Hájek³, Kamil Dvořák⁴, Petr Fixa⁵, Eva Čermaková⁶

¹ Základna radiodiagnostiky a intervenční radiologie IKEM, Praha

² Radiologická klinika LF a FN, Hradec Králové

³ Radiodiagnostické oddělení, Pardubická krajská nemocnice a.s., Pardubice

⁴ Fresenius Medical Care, D.S., Pardubice

⁵ Gerontometabolická klinika LF a FN, Hradec Králové

⁶ Katedra biofyziky FN, Hradec Králové

Aim: To evaluate impact of intravascular iodinated contrast medium on residual renal function in hemodialysed patiens.

Method: Two groups of hemodialysed patiens with clinically significant residual renal function (minimally 500 ml of urine per day) were studied. The patients from the first group were given isoosmolal contrast agent iodixanol (Visipaque GE Healthcare, United Kingdom) in concentration of iodine 320 mg/ml with osmolality 290 mOsm/kg of water during endovascular procedure. The second control group was followed without contrast medium administered. The evaluated group included 42 patients whom were given 99.3 ml of iodixanol in average (range from 60 to 180 ml). The control group included 45 patients. Residual diuresis and clearance of creatinine had been evaluated in the both groups following 6 months.

Results: There was no statistically significant difference found between both groups in daily volume of urine (p = 0.855) and clearance of creatinine (p = 0.573).

Conclusion: Residual diuresis is not significantly influenced by intravascular administration of isotonic iodinated contrast agent (iodixanol) in range of volume from 60 to 180 ml in comparison to natural decrease of residual renal functions.

Keywords: hemodialysis, iodixanol, residual diuresis, residual renal functions

Accepted: October 15, 2008; Published: December 1, 2008  Show citation