Ces radiol. 2010, 64(2):116-120

Transarterial chemoembolisation of the hepatocellular carcinoma in patients indicated to liver transplantationOriginal article

Jarmila Laštovičková, Jan Peregrin
IKEM, Praha

Aim: Presentation of our own experience with conventional chemoembolisation and chemoembolisation with drug eluting beads in patients with hepatocellular carcinoma before liver transplantation.

Method: 13 patients with hepatocellular carcinoma in cirhotic liver were treated with transarterial chemoembolization in 2008 and 2009 prior to liver transplantation. There were 7 conventional chemoembolization procedures (lipiodol and doxorubicin) and 6 TACE with doxorubicin loading on drug eluting bead.

Results: On CT examination 4-6 weeks after procedure we found complete lipiodol uptake in the tumor in 5 patients, large tumor necrosis after DEB-TACE also in 5 patients. Eight patients were transplanted with mean period on waiting list 3.4 month. Five patients are without recurrence of tumor with good liver function. One patient died in the early posttransplantation period. Recurrence of hepatocellular carcinoma was found in 2 patients.

Conclusion: TACE is safe method of neoadjuvant therapy in patients with HCC prior to liver transplantation.

Keywords: transarterial chemoembolization, hepatocellular carcinoma, liver transplantation, DC Bead

Accepted: April 15, 2010; Published: June 1, 2010  Show citation

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Laštovičková J, Peregrin J. Transarterial chemoembolisation of the hepatocellular carcinoma in patients indicated to liver transplantation. Ces radiol. 2010;64(2):116-120.
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    References

    1. Oliverius M, Studeník P. Transplantace jater pro hepatocelulární karcinom. Folia Gastroenterol Hepatol 2005; 3(1): 69-77.
    2. Golzarian J, Sun S, Sharafuddin MJ. Vascular Embolotherapy. Berlin Heidelberg: Springer-Verlag 2006; 129-140. Go to original source...
    3. Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patiens with cirrhosis. N Engl J med 1996; 334: 693-699. Go to original source... Go to PubMed...
    4. Belghiti J, Carr BI, Greig PD, et al. Treatment before Liver Transplantation for HCC. Annals of Surgical Oncology 2008; 15(4): 993-1000. Go to original source... Go to PubMed...
    5. Llovet JM, Futer J, Bruix J. The Barcelona Approach: Diagnosis, Staging, and Treatment of Hepatocellular Carcinoma Liver Transplantation 2004; 2(10): 115-120. Go to original source... Go to PubMed...
    6. Llovet JM, Real MI, Montana X, et al. Arterial embolisation or chemoembolisation versus symptomatic treatment in patiens with unresectable hepatocellural carcinoma: a randomised controlled trial. Lancet 2002; 359: 1734-1739. Go to original source... Go to PubMed...
    7. Malagari K. Drug-eluting particles in the treatment of HCC: chemoembolization with doxorubicin-loaded DC Bead Expert Rev. Anticancer ther 2008; 8(10): 1643-1650. Go to original source... Go to PubMed...
    8. Malagari K, Pomoni M, Kelekis A, et al. Prospective randomized Comparison of Chemoembolization with Doxorubicin-Eluting Beds and Bland Embolization with BeadBlock for Hepatocellular Carcinoma. Cardiovasc Intervent Radiol 2009; published online: 24 November 2009. Go to original source...
    9. Lammer J, Malagari K, Vogl T, et al. Prospective Randomized Study of Doxorubicin-Eluting.Bead Embolization in the Treatment of Hepatocellular Carcinoma: Results of the PRECISION V Study. Cardiovasc Intervent Radiol 2009; published on line: 12 November 2009.
    10. Kim DJ, Choi MS, Lee JH, et al. Milan kriteria are useful predictors for favorable outcomes in hepatocellular carcinoma patiens undergoing liver transplantation after transarterial chemoembolization. World J Gastroenterol 2006; 12(43): 6992-6997. Go to original source... Go to PubMed...
    11. Hoffman K, Glimm H, Radeleff B, et al. Prospective, randomized, double-blind, multi-center, Phase III clinical study on transarterial chemoembolization (TACE) combined with Sorafenib versus TACE plus placebo in patiens with hepatocellular cancer before liver transplantation. BMC Cancer 2008; 8: 349. Go to original source... Go to PubMed...

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