Ces radiol. 2010, 64(4):249-258

Hybrid imaging SPECT/CT with 111In-octreotideReview article

Jiří Ferda, Eva Ferdová, Alexander Malán, Jan Záhlava
Klinika zobrazovacích metod LF UK a FN, Plzeň

Hybrid imaging SPECT/CT with the application of the 111In-octreotide uses the combination of the imaging of morfology by multidetector-row computed tomography and the the imaging of the somatostatine-receptor density after application of somatostatine analogous substance. The hybrid imaging SPECT/CT includes imaging with dedicated system or off-line fusion of SPECT and CT data, due to the limited spatioal reconstruction of SPECT the results of both approaches could be comparable. Octreotide is able to bind to the somatostatin receptor subtype 2, which gene is expressed in many tumors of neuroendocrine origin especially in carcinoid and gastrinoma. The octreotide affinity to some malignant tumors; those of neuroendocrine origine - small cellular bronchogenic carcinoma and neuroblastoma; and to some mesodermal tumors like meningeoma; is very well known. The combination of the information derived from full diagnostic contrast enhanced MDCT and 111In-octreotide accumulation provides the synthesis of vascularisation and somatostatine receptor density. This information is useful in detection of the neuroendocrine tumor of unknown localization (presented as carcinoid-syndrome or Zollinger-Ellison syndrome), when the therapeutic effect should be estimated - somatostatine therapy or therapy using the somatostatin-analogon bearing the 111In or 90Y.

Keywords: hybrid imaging, 111In-octreotide, SPECT/CT, neuroendocrine tumors, carcinoid
Grants and funding:

Práce byla podpořena výzkumným projektem MSM 0021620819.

Accepted: November 1, 2010; Published: December 1, 2010  Show citation

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Ferda J, Ferdová E, Malán A, Záhlava J. Hybrid imaging SPECT/CT with 111In-octreotide. Ces radiol. 2010;64(4):249-258.
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