Ces radiol. 2021, 75(1):45-51 | DOI: 10.55095/CesRadiol2021/004

Clinical and economical potential of PET/MRI in rectal cancer stagingOriginal article

Alexandra Litavcová1, Marek Dostál1,2, Miloš Keřkovský1, Simon Smrčka1, Andrea Šprláková-Puková1, Marek Mechl1
1 Klinika radiologie a nukleární medicíny LF MU a FN, Brno
2 Biofyzkální ústav LF MU, Brno

Aim: The aim of this paper is to present clinical-economic aspects of rectal cancer staging using 18F-FDG-PET/MRI.

Methods: For rectal cancer staging was designed the PET/MRI protocol, which maximizes diagnostic performance of this imaging method in a minimum of time. This protocol includes PET/MRI from skull base to mid-thigh, dynamic contrast enhanced MRI of liver with hepatospecific contrast agent, MRI of the rectum, sequence for lung evaluation. We compare 4 different scenarios using different imaging methods for rectal cancer staging. For each scenario we calculate total radiation exposure and economical costs.

Results: From 2018 to 2020 our department performed 3950 PET/MRI examinations, 867 (21,95%) were performed by PET/MRI protocol for rectal cancer staging. The clinical benefit of PET/MRI in rectal cancer staging is the speeding-up of the diagnostic process. According to the proposed economic-radiation situations, the scenario using 18F-FDG-PET/MRI for rectal cancer staging was 2nd most economical with the lowest radiation exposure.

Conclusion: PET/MRI for rectal cancer allows as a "one-stop-shop" imaging method detailed evaluation of locoregional finding and distant dissemination in one diagnostic setting, speeds up diagnostic process and reduces radiation exposure of patients.

Keywords: PET/MRI, rectal cancer, staging, economic aspects
Grants and funding:

Podpořeno MZ ČR - RVO (FNBr, 65269705) a MUNI/A/1342/2020.

Accepted: January 31, 2021; Published: March 1, 2021  Show citation

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Litavcová A, Dostál M, Keřkovský M, Smrčka S, Šprláková-Puková A, Mechl M. Clinical and economical potential of PET/MRI in rectal cancer staging. Ces radiol. 2021;75(1):45-51. doi: 10.55095/CesRadiol2021/004.
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    References

    1. Kekelidze M, D'Errico L, Pansini M, Tyndall A, Hohmann J. Colorectal cancer: Current imaging methods and future perspectives for the diagnosis, staging and therapeutic response evaluation. World J Gastroenterol 2013; 19(46): 8502-8514. Go to original source... Go to PubMed...
    2. Balyasnikova S, Brown G. Optimal Imaging Strategies for Rectal Cancer Staging and Ongoing Management. Curr Treat Options Oncol [Internet]. 2016 [cited 2021 Jan 28]; 17. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891388/ Go to original source...
    3. Glynne-Jones R, Wyrwicz L, Tiret E, Brown G, Rödel C, Cervantes A, et al. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†. Annals of Oncology 2017; 28: iv22-40. Go to original source... Go to PubMed...
    4. Bohatá Š. The significance of magnetic resonance imaging rectal cancer. Onkologie 2017; 11(2): 61-65. Go to original source...
    5. Catalano OA, Lee SI, Parente C, Cauley C, Furtado FS, Striar R, et al. Improving staging of rectal cancer in the pelvis: the role of PET/MRI. Eur J Nucl Med Mol Imaging [Internet] 2020 Oct 9 [cited 2021 Jan 28]. Available from: https://doi.org/10.1007/s00259-020-05036-x Go to original source... Go to PubMed...
    6. Abdel-Nabi H, Doerr RJ, Lamonica DM, Cronin VR, Galantowicz PJ, Carbone GM, et al. Staging of primary colorectal carcinomas with fluorine-18 fluorodeoxyglucose whole-body PET: correlation with histopathologic and CT findings. Radiology 1998; 206(3): 755-760. Go to original source... Go to PubMed...
    7. Rutegård MK, Båtsman M, Axelsson J, Brynolfsson P, Brännström F, Rutegård J, et al. PET/MRI and PET/CT hybrid imaging of rectal cancer - description and initial observations from the RECTOPET (REctal Cancer trial on PET/MRI/CT) study. Cancer Imaging [Internet] 2019 Jul 23 [cited 2021 Jan 28]; 19. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651930/ Go to original source... Go to PubMed...
    8. Queiroz MA, Ortega CD, Ferreira FR, Nahas SC, Cerri GG, Buchpiguel CA. Diagnostic accuracy of FDG-PET/MRI versus pelvic MRI and thoracic and abdominal CT for detecting synchronous distant metastases in rectal cancer patients. Eur J Nucl Med Mol Imaging 2021; 48(1): 186-195. Go to original source... Go to PubMed...
    9. Strasberg SM, Dehdashti F. Role of FDG-PET staging in selecting the optimum patient for hepatic resection of metastatic colorectal cancer. Journal of Surgical Oncology 2010; 102(8): 955-959. Go to original source... Go to PubMed...
    10. Huang S, Savic D, Yang J, Shrestha U, Seo Y. The Effect of Magnetic Field on Positron Range and Spatial Resolution in an Integrated Whole-Body Time-Of-Flight PET/MRI System. IEEE Nucl Sci Symp Conf Rec (1997) [Internet] 2014 Nov [cited 2021 Jan 28]; 2014. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828037/
    11. Sekine T, Delso G, Zeimpekis KG, de Galiza Barbosa F, ter Voert EEGW, Huellner M, et al. Reduction of 18F-FDG Dose in Clinical PET/MR Imaging by Using Silicon Photomultiplier Detectors. Radiology 2017; 286(1): 249-259. Go to original source... Go to PubMed...
    12. Výkony - Zdravotní výkony [Internet] [cited 2021 Jan 28]. Available from: https://szv.mzcr.cz/Vykon
    13. Yoon JH, Lee JM, Chang W, Kang H, Bandos A, Lim H, et al. Initial M Staging of Rectal Cancer: FDG PET/MRI with a Hepatocyte-specific Contrast Agent versus Contrast-enhanced CT. Radiology 2019; 294(2): 310-319. Go to original source... Go to PubMed...
    14. Kang B, Lee JM, Song YS, Woo S, Hur BY, Jeon JH, et al. Added Value of Integrated Whole-Body PET/MRI for Evaluation of Colorectal Cancer: Comparison With Contrast-Enhanced MDCT. American Journal of Roentgenology 2016; 206(1): W10-20. Go to original source... Go to PubMed...
    15. McCollough C, Cody D, Edyvean S, Geise R, Gould B, Keat N, et al. The Measurement, Reporting, and Management of Radiation Dose in CT [Internet]. AAPM 2008 Jan [cited 2021 Jan 28]. Available from: https://www.aapm.org/pubs/reports/detail.asp?docid=97 Go to original source...
    16. Věstník č. 2/2016 [Internet]. Ministerstvo zdravotnictví [cited 2021 Jan 28]. Available from: https://www.mzcr.cz/vestnik/vestnik-c-2-2016/
    17. Martí-Climent JM, Prieto E, Morán V, Sancho L, Rodríguez-Fraile M, Arbizu J, et al. Effective dose estimation for oncological and neurological PET/CT procedures. EJNMMI Res [Internet] 2017 Apr 24 [cited 2021 Jan 28]; 7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403773/ Go to original source... Go to PubMed...
    18. Catalano OA, Coutinho AM, Sahani DV, Vangel MG, Gee MS, Hahn PF, et al. Colorectal cancer staging: comparison of whole-body PET/CT and PET/MRI. Abdom Radiol 2017; 42(4): 1141-1151. Go to original source... Go to PubMed...
    19. Sivesgaard K, Larsen LP, Sørensen M, Kramer S, Schlander S, Amanavicius N, et al. Diagnostic accuracy of CE-CT, MRI and FDG PET/CT for detecting colorectal cancer liver metastases in patients considered eligible for hepatic resection and/or local ablation. Eur Radiol 2018; 28(11): 4735-4747. Go to original source... Go to PubMed...
    20. Paspulati RM, Partovi S, Herrmann KA, Krishnamurthi S, Delaney CP, Nguyen NC. Comparison of hybrid FDG PET/MRI compared with PET/CT in colorectal cancer staging and restaging: a pilot study. Abdom Imaging 2015; 40(6): 1415-1425. Go to original source... Go to PubMed...
    21. Burris NS, Johnson KM, Larson PEZ, Hope MD, Nagle SK, Behr SC, et al. Detection of Small Pulmonary Nodules with Ultrashort Echo Time Sequences in Oncology Patients by Using a PET/MRI System. Radiology 2016; 278(1): 239-246. Go to original source... Go to PubMed...
    22. Chandarana H, Heacock L, Rakheja R, DeMello LR, Bonavita J, Block TK, et al. Pulmonary nodules in patients with primary malignancy: comparison of hybrid PET/MRI and PET/CT imaging. Radiology 2013; 268(3): 874-881. Go to original source... Go to PubMed...

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