Ces radiol. 2021, 75(4):285-288 | DOI: 10.55095/CesRadiol2021/035

Central vein sign and iron rim sign in multiple sclerosisReview article

Andrea Burgetová1, Petr Dušek1,2, Romana Burgetová1,3, Adam Pudlač1, Lukáš Lambert1
1 Radiodiagnostická klinika 1. LF UK a VFN, Praha
2 Neurologická klinika 1. LF UK a VFN, Praha
3 Radiodiagnostická klinika 3. LF UK a FNKV, Praha

In this article, we introduce less-known features of white matter lesions in patients with multiple sclerosis, which can be identified on MR sequences sensitive to changes in local susceptibility. The central vein sign indicates a finding of a vein passing through a white matter lesion and can be found in more than half of the white matter lesions in patients with multiple sclerosis. The iron rim sign is a thin annular rim of a white matter lesion caused by accumulation of iron laden macrophages and microglia, typically in chronic-active lesions.

Keywords: multiple sclerosis, magnetic resonance imaging, white matter lesion, susceptibility weighted imaging, iron
Grants and funding:

Podpořeno z programového projektu Ministerstva zdravotnictví ČR - NV18-08-00062, RVO VFN64165.

Accepted: December 15, 2021; Published: December 1, 2021  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Burgetová A, Dušek P, Burgetová R, Pudlač A, Lambert L. Central vein sign and iron rim sign in multiple sclerosis. Ces radiol. 2021;75(4):285-288. doi: 10.55095/CesRadiol2021/035.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Keřkovský M, Stulík J, Obhlídalová I, Praksová P, Bednařík J, Dostál M, et al. Moderní techniky MR zobrazení u roztroušené sklerózy. Cesk Slov Neurol N 2017; 80(6): 647-657. Go to original source...
    2. Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol 2018; 17(2): 162-173. Go to original source... Go to PubMed...
    3. Filli L, Hofstetter L, Kuster P, Traud S, Mueller-Lenke N, Naegelin Y, et al. Spatiotemporal distribution of white matter lesions in relapsing-remitting and secondary progressive multiple sclerosis. Mult Scler 2012; 18(11): 1577-1584. Go to original source... Go to PubMed...
    4. Sati P, Oh J, Constable RT, Evangelou N, Guttmann CRG, Henry RG, et al. The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative. Nat Rev Neurol 2016; 12(12): 714-722. Go to original source... Go to PubMed...
    5. Clarke MA, Pareto D, Pessini-Ferreira L, Arrambide G, Alberich M, Crescenzo F, et al. Value of 3T Susceptibility-Weighted Imaging in the Diagnosis of Multiple Sclerosis. Am J Neuroradiol 2020; 41(6): 1001-1008. Go to original source... Go to PubMed...
    6. Burgetová A, Seidl Z, Vaněčková M, Krásenský J, Horáková D. Magnetická rezonanční relaxometrie u roztroušené sklerózy - měření T2 relaxačního času v centrální šedé hmotě. Cesk Slov Neurol N 2010; 106(1): 26-31.
    7. Nair JR, van Hecke W, de Belder F, Venstermans C, van den Hauwe L, van Goethem J, et al. High-Resolution Susceptibility-Weighted Imaging at 3 T With a 32-Channel Head Coil: Technique and Clinical Applications. Am J Roentgenol 2010; 195(4): 1007-1014. Go to original source... Go to PubMed...
    8. Castellaro M, Tamanti A, Pisani AI, Pizzini FB, Crescenzo F, Calabrese M. The Use of the Central Vein Sign in the Diagnosis of Multiple Sclerosis: A Systematic Review and Meta-analysis. Diagnostics (Basel) 2020; 10(12): E1025. Go to original source... Go to PubMed...
    9. Sinnecker T, Clarke MA, Meier D, Enzinger C, Calabrese M, de Stefano N, et al. Evaluation of the Central Vein Sign as a Diagnostic Imaging Biomarker in Multiple Sclerosis. JAMA Neurology 2019; 76(12): 1446-1456. Go to original source... Go to PubMed...
    10. George IC, Sati P, Absinta M, Cortese IC, Sweeney EM, Shea CD, et al. Clinical 3-tesla FLAIR* MRI improves diagnostic accuracy in multiple sclerosis. Mult Scler 2016; 22(12): 1578-1586. Go to original source... Go to PubMed...
    11. Sinnecker T, Dörr J, Pfueller CF, Harms L, Ruprecht K, Jarius S, et al. Distinct lesion morphology at 7-T MRI differentiates neuromyelitis optica from multiple sclerosis. Neurology 2012; 79(7): 708-714. Go to original source... Go to PubMed...
    12. Maggi P, Absinta M, Grammatico M, Vuolo L, Emmi G, Carlucci G, et al. Central vein sign differentiates Multiple Sclerosis from central nervous system inflammatory vasculopathies. Ann Neurol 2018; 83(2): 283-294. Go to original source... Go to PubMed...
    13. Mistry N, Abdel-Fahim R, Samaraweera A, Mougin O, Tallantyre E, Tench C, et al. Imaging central veins in brain lesions with 3-T T2*-weighted magnetic resonance imaging differentiates multiple sclerosis from microangiopathic brain lesions. Mult Scler 2016; 22(10): 1289-1296. Go to original source... Go to PubMed...
    14. Maggi P, Fartaria MJ, Jorge J, La Rosa F, Absinta M, Sati P, et al. CVSnet: A machine learning approach for automated central vein sign assessment in multiple sclerosis. NMR Biomed 2020; 33(5): e4283. Go to original source... Go to PubMed...
    15. AlTokhis AI, AlOtaibi AM, Felmban GA, Constantinescu CS, Evangelou N. Iron Rims as an Imaging Biomarker in MS: A Systematic Mapping Review. Diagnostics (Basel) 2020; 10(11): 968. Go to original source... Go to PubMed...
    16. Kaunzner UW, Kang Y, Zhang S, Morris E, Yao Y, Pandya S, et al. Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions. Brain 2019; 142(1): 133-145. Go to original source... Go to PubMed...
    17. Absinta M, Sati P, Schindler M, Leibovitch EC, Ohayon J, Wu T, et al. Persistent 7-tesla phase rim predicts poor outcome in new multiple sclerosis patient lesions. J Clin Invest 2016; 126(7): 2597-2609. Go to original source... Go to PubMed...
    18. Suthiphosuwan S, Sati P, Absinta M, Guenette M, Reich DS, Bharatha A, et al. Paramagnetic Rim Sign in Radiologically Isolated Syndrome. JAMA Neurology 2020; 77(5): 653-635. Go to original source... Go to PubMed...
    19. Chawla S, Kister I, Wuerfel J, Brisset J-C, Liu S, Sinnecker T, et al. Iron and Non-Iron-Related Characteristics of Multiple Sclerosis and Neuromyelitis Optica Lesions at 7T MRI. Am J Neuroradiol 2016; 37(7): 1223-1230. Go to original source... Go to PubMed...
    20. Maggi P, Sati P, Nair G, Cortese ICM, Jacobson S, Smith BR, et al. Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study. Ann Neurol 2020; 88(5): 1034-1042. Go to original source... Go to PubMed...
    21. Bozin I, Ge Y, Kuchling J, Dusek P, Chawla S, Harms L, et al. Magnetic Resonance Phase Alterations in Multiple Sclerosis Patients with Short and Long Disease Duration. PLoS One 2015; 10(7): e0128386. Go to original source... Go to PubMed...
    22. Stüber C, Pitt D, Wang Y. Iron in Multiple Sclerosis and Its Noninvasive Imaging with Quantitative Susceptibility Mapping. Int J Mol Sci 2016; 17(1): 100. Go to original source... Go to PubMed...
    23. Dal-Bianco A, Grabner G, Kronnerwetter C, Weber M, Höftberger R, Berger T, et al. Slow expansion of multiple sclerosis iron rim lesions: pathology and 7T magnetic resonance imaging. Acta Neuropathol 2017; 133(1): 25-42. Go to original source... Go to PubMed...

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content