Ces radiol. 2023, 77(1):35-40 | DOI: 10.55095/CesRadiol2023/006

Platelet function testing - a single centre experienceOriginal article

Pavol Vigláš1,2, Filip Cihlář1, Pavla Bradáčová3, Aleš Hejčl4, David Černík5, Jan Raupach2, Lucie Lejnarová1
1 Radiologická klinika FZS UJEP a Krajské zdravotní a.s. - Masarykovy nemocnice v Ústí nad Labem, o.z.
2 Radiologická klinika LF UK a FN, Hradec Králové
3 Oddělení klinické hematologie, Krajská zdravotní a.s. - Masarykova nemocnice v Ústí nad Labem, o.z.
4 Neurochirurgická klinika FZS UJEP a Krajské zdravotní a.s. - Masarykovy nemocnice v Ústí nad Labem, o.z.
5 Neurologické oddělení, Krajská zdravotní a.s. - Masarykova nemocnice v Ústí nad Labem, o.z.

Purpouse: Evaluation of the laboratory effectiveness of the antiplatelet drugswe use: clopidogrel, ticagrelor, aspirin. Assessment of the effectiveness ofticagrelor as an alternative treatment in patients with in vitro resistance,or HTPR (high on-treatment platelet reactivity) to clopidogrel.

Methods: In our set of patients, the effectiveness of antiplatelet drugs wastested using the light transmission aggregometry (LTA) method from 16. 9. 2020to 5. 12. 2022. The effectiveness of treatment in patients switched to analternative medicine was monitored and the success of the change in therapywas evaluated.

Results: In the monitored period, a total of 529 blood samples were tested forclopidogrel (n = 216), ticagrelor (n = 59) and aspirin (n = 254). The efficacyof clopidogrel treatment was 45.4 %. On the other hand, the efficacy ofticagrelor was 93.2 %, statistically significantly higher (p < 0.000). In caseof conversion from clopidogrel to ticagrelor, treatment was successful in 49of 54 patients (90.7 %).

Conclusion: For the antiplatelet drugs tested, statistically significantdifferences in the effectiveness were demonstrated. In the case of clopidogrel,ticagrelor is a suitable alternative, significantly reducing incidence ofHTPR. The number of patients with HTPR undergoing stent/flow diverterimplantation can be significantly reduced by including platelet functiontesting in the algorithm of endovascular procedures.

Keywords: aspirin, clopidogrel, HTPR, antiplatelet therapy, ticagrelor,thromboembolic complications

Published: March 1, 2023  Show citation

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Vigláš P, Cihlář F, Bradáčová P, Hejčl A, Černík D, Raupach J, Lejnarová L. Platelet function testing - a single centre experience. Ces radiol. 2023;77(1):35-40. doi: 10.55095/CesRadiol2023/006.
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