Ces radiol. 2025, 79(3):151-159 | DOI: 10.55095/CesRadiol2025/027

Imaging of the brain with photon-counting CTReview article

Jiří Ferda, Filip Heidenreich, Jan Pernický, Barbora Ferdová, Pavel Nedbal, Tomáš Vendiš, Jan Baxa
Klinika zobrazovacích metod LF UK a FN, Plzeň

Photon-counting CT is the most significant innovation in CT technology since the introduction of multidetector scanning techniques at the end of the last century. It allows the use of maximum high spatial resolution with noise minimization to identify very subtle changes and the possibility of a better interactive display of the difference in the behavior of brain tissue when differentiating individual types of brain edema and differentiating malatic tissue. A significant use is the rapid identification of saturation with iodine contrast material in control examinations following intra-arterial interventions. Compared to energy-integrating CT, a significant shift is the possibility of optimizing imaging due to the greater accuracy of distinguishing structures in different pathologies when using a standardized imaging protocol.

Keywords: photon-counting CT, brain CT, spectral imaging, intracerebral bleeding, brain edema.

Accepted: August 31, 2025; Published: December 1, 2025  Show citation

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Ferda J, Heidenreich F, Pernický J, Ferdová B, Nedbal P, Vendiš T, Baxa J. Imaging of the brain with photon-counting CT. Ces radiol. 2025;79(3):151-159. doi: 10.55095/CesRadiol2025/027.
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    References

    1. . Pourmorteza A, Symons R, Reich DS, et al. Photon-Counting CT of the Brain: In Vivo Human Results and Image-Quality Assessment. Am J Neuroradiol. 2017; 38(12): 2257-2263. Go to original source...
    2. . Flohr T, Petersilka M, Henning A, Ulzheimer S, Ferda J, Schmidt B. Photon-counting CT review. Phys Med. 2020; 79: 126-136. Go to original source...
    3. . Ferda J, Vendiš T, Flohr T, et al. Computed tomography with a full FOV photon-counting detector in a clinical setting, the first experience. Eur J Radiol. 2021; 137: 109614. doi: 10.1016/j.ejrad.2021.109614 [Epub 2021 Feb 24]. PMID: 33657475. Go to original source... Go to PubMed...
    4. . Stein T, Lang F, Rau S, et al. Photon-counting detector CT of the brain reduces variability of Hounsfield units and has a mean offset compared with energy-integrating detector CT. Am J Neuroradiol. 2025 Jul 1: ajnr.A8910. doi: 10.3174/ajnr.A8910 [Epub ahead of print]. PMID: 40592542. Go to original source... Go to PubMed...
    5. . Greffier J, Villani N, Defez D, Dabli D, Si-Mohamed S. Spectral CT imaging: Technical principles of dual-energy CT and multi-energy photon-counting CT. Diagn Interv Imaging. 2023; 104(4): 167-177. Go to original source...
    6. . Abel F, Schubert T, Winklhofer S. Advanced Neuroimaging With Photon-Counting Detector CT. Invest Radiol. 2023; 58(7): 472-481. Go to original source...
    7. . Madhavan AA, Bathla G, Benson JC, Diehn FE, Nagelschneider AA, Lehman VT. High yield clinical applications for photon counting CT in neurovascular imaging. Br J Radiol. 2024; 97(1157): 894-901. Go to original source...
    8. . Schmitt N, Wucherpfennig L, Rotkopf LT, et al. Metal artifacts and artifact reduction of neurovascular coils in photon-counting detector CT versus energy-integrating detector CT - in vitro comparison of a standard brain imaging protocol. Eur Radiol. 2023; 33(2): 803-811. Go to original source... Go to PubMed...
    9. . Ferda J, Novák M, Mírka H, et al. The assessment of intracranial bleeding with virtual unenhanced imaging by means of dual-energy CT angiography. Eur Radiol. 2009; 19(10): 2518-2522. Go to original source... Go to PubMed...
    10. . Vrbaski S, Bache S, Rajagopal J, Samei E. Quantitative performance of photon- counting CT at low dose: Virtual monochromatic imaging and iodine quantification. Med Phys. 2023; 50(9): 5421-5433. Go to original source... Go to PubMed...

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