Ces radiol. 2007, 61(1):32-36

Extramedullary hematopoiesis with predominant renal involvementCase report

Hynek Mírka1, Kristýna Ohlídalová1, Jiří Ferda1, Samuel Vokurka2, Miroslava Schutzová2, Petr Mukenšnabl3, František Fakan3, Petr Pužman4
1 Radiodiagnostická klinika LF UK a FN, Plzeň
2 Hematoonkologické oddělení FN, Plzeň
3 Šiklův patologicko-anatomický ústav LF UK a FN, Plzeň
4 Klinika tuberkulózy a respiračních nemocí LF UK a FN, Plzeň

Aim: Extramedullary hematopoiesis is a compensatory mechanism associated with bone marrow insufficiency. Most commonly it can be observed in chronic anemias (e.g. thalassemia) and myelofibrosis. Less frequently it may occur in malignant infiltration and toxic or radiation damage to the bone marrow.

Method: Our case study demonstrates ultrasound and computed tomography findings in an unusual case of extramedullary hematopoiesis involving kidneys in a patient with myelofibrosis. Findings in other organs and magnetic resonance features of this rare condition are also discussed.

Conclusion: Imaging findings in extramedullary hematopoiesis are usualy non-specific and may mimic more serious diseases. Ultrasound, computed tomography, and magnetic resonance findings discussed in this paper in patients with chronic anemias or pathologic processes destructing bone marrow evoke suspition of this condition but final diagnosis necessitates histologic verification.

Keywords: extramedullary hematopoiesis, helical computed tomography, myelofibrosis, ultrasonography

Accepted: December 15, 2006; Published: March 1, 2007  Show citation

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Mírka H, Ohlídalová K, Ferda J, Vokurka S, Schutzová M, Mukenšnabl P, et al.. Extramedullary hematopoiesis with predominant renal involvement. Ces radiol. 2007;61(1):32-36.
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    References

    1. Schnuelle P, Waldherr R, Lehmann KJ, Woenckhaus J, Back W, Niemir Z, van der Woude FJ. Idiopathic myelofibrosis with extramedullary hematopoiesis in the kidneys. Clin Nephrol 1999; 52(4): 256-262.
    2. Tunaci M, Tunaci A, Engin G, Ozkorkmaz B, Dincol G, Acunas G, Acunas B, et al. Imaging features of thalassemia. Eur Radiol 1999; 9(9): 1804-1809. Go to original source... Go to PubMed...
    3. Guermazi A, De Kerviler E, Cazals-Hatem D, Zagdanski AM, Frija J. Imaging findings in patients with myelofibrosis. Eur Radiol 1999; 9(7): 1366-1375. Go to original source... Go to PubMed...
    4. Aytac S, Fitoz S, Akyar S, Atasoy C, Erekul S. Focal intrahepatic extramedullary hematopoiesis: color Doppler US and CT findings. Abdom Imaging 1999; 24(4): 366-368. Go to original source... Go to PubMed...
    5. Coyne JD. Extramedullary haemopoiesis. J Clin Pathol 2005; 58(4): 448. Go to original source... Go to PubMed...
    6. Kwak HS, Lee JM. CT findings of extramedullary hematopoiesis in the thorax, liver and kidneys, in a patient with idiopathic myelofibrosis. J Korean Med Sci 2000; 15(4): 460-462. Go to original source... Go to PubMed...
    7. Castelli R, Graziadei G, Karimi M, Cappellini MD. Intrathoracic masses due to extramedullary hematopoiesis. Am J Med Sci 2004; 328(5): 299-303. Go to original source... Go to PubMed...
    8. Gupta P, Naran A, Auh YH, Chung JS. Focal Intrahepatic Extramedullary Hematopoiesis Presenting as Fatty Lesions. AJR 2004; 182(4): 1031-1032. Go to original source... Go to PubMed...
    9. Pauček B, Indrák K, Heřman M, Roček V. Tuková konverze ložisek extramedulární hematopoézy. Čes Radiol 2002; 56(6): 335-338.
    10. Peker Ş, Çelebisoy M, Akkol İ, Bezircioğlu H. Paraplegia Due to Extramedullary Hematopoiesis in the Thalassemia Intermedia. Turk J Med Sci 2003; 33: 341-344.
    11. Shawker TH, Hill M, Hill S, Garra B. Ultrasound appearance of extramedullary hematopoiesis. Journal of Ultrasound in Medicine 1987; 6(6): 283-290. Go to original source... Go to PubMed...
    12. Lee KJ, Boswell WD. Extramedullary hematopoiesis. Applied Radiology On-line 2005; 34(10): nestr. (http://www.appliedradiology.com)
    13. Gibbins J, Pankhurst T, Murray J, McCafferty I, Baiden-Amissahk K, Shafeek S, Lipkin GW. Extramedullary haematopoiesis in the kidney: a case report and review of literature. Clin Lab Haem 2005; 27(6): 391-394. Go to original source... Go to PubMed...
    14. La Fianza A, Torretta L, Spinazzola A. Extramedullary hematopoiesis in chronic myelofibrosis encasing the pelvicaliceal system and perirenal spaces: CT findings. Urol Int 2005; 75(3): 281-284. Go to original source... Go to PubMed...
    15. Pamuk ON, Pamuk GE, Altiparmak MR, Sonsuz A, Solakoglu S, Kilicaslan I. Nephrotic syndrome associated with agnogenic myeloid metaplasia. Leuk Lymphoma 2002; 43(3): 661-663. Go to original source... Go to PubMed...

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