Ces radiol. 2012, 66(1):9-17

Prostate imaging with 3T MRI in patiens with elevated PSA levelsOriginal article

Jiří Ferda¹, Milan Hora², Ondřej Hes³, Jan Kastner¹, Eva Ferdova¹, Hynek Mírka¹, Jan Baxa¹, Filip Heidenreich¹, Jindřich Fínek⁴, Boris Kreuzberg¹

¹ Klinika zobrazovacích metod LF UK a FN, Plzeň

² Urologická klinika LF UK a FN, Plzeň

³ Šiklův ústav patologické anatomie LF UK a FN, Plzeň

⁴ Onkologické a radioterapeutické oddělení FN, Plzeň

Aim: To assess the clinical value of magnetic resonance with 3T (3TMRI) in detection of the prostate carcinoma and to confront the results with those of trans-rectal biopsy.

Method: 86 men with elevated PSA with low free-to-total ratio underwent the 3TMRI including T2 weighted images, diffusion weighted imaging, 3D-chemical-shift imaging and contrast-enhanced dynamic T1 weighted imaging. The evaluation protocol consists of the assessments of morphology, diffusion restriction, choline concentration and the pharmacokinetic of gadolinium-based contrast agent. The bioptic assessment was performed in every case.

Results: The overall sensitivity reached 97.62%, specificity 68.18%, positive predictive value 74.55% and negative predictive value 96.77%. Fourteen positive cases included two cases of prostatitis, three cases of high-grade prostatic intraductal neoplasia and nine cases of the adenomyomatous hyperplasia.

Conclusion: The integral imaging protocol using 3T MRI is a robust tool to detect prostatic carcinoma in men with pathological PSA values.

Keywords: prostate carcinoma, 3T MRI, MR-spectroscopy, diffusion weighted imaging

Grants and funding:

Práce byla podpořena výzkumným projektem MSM 0021620819.

Accepted: January 15, 2012; Published: March 1, 2012  Show citation