Ces radiol. 2018, 72(4):268-273 | DOI: 10.55095/CesRadiol2018/037

Changes of fractional anisotropy of the cerebral white matter in first-episode schizophreniaOriginal article

Ondřej Slezák1,2, Jan Žižka3, Antonín Škoch4,5, David Bayer6, Filip Španiel5, Jaroslav Tintěra2,4, Jiří Jandura1,2, Pavel Eliáš1,2
1 Radiologická klinika LF UK, Hradec Králové
2 Radiologická klinika FN, Hradec Králové
3 Department of Radiology, University Hospital of Umeå, Daniel Naezéns väg, Umeå, Sweden
4 Základna radiodiagnostiky a intervenční radiologie IKEM, Praha
5 Národní ústav duševního zdraví, Klecany
6 Psychiatrická klinika FN, Hradec Králové

Purpose: To assess microstructural changes of the cerebral white matter in the earliest stage of schizophrenia.

Methods: Magnetic resonance was used to prospectively compare fractional anisotropy of the white matter between subjects after the first episode of schizophrenia (n = 23) and healthy controls (n = 23). Diffusion tensor data obtained from multidirectional diffusion weighted sequence were analysed by using Tract-Based Spatial Statistics (TBSS).

Results: Extensive areas of decreased fractional anisotropy (FA) were found in the white matter after the first episode of schizophrenia, affecting most of the white matter tracts. No areas of significantly increased FA were found when compared to the healthy control group.

Conclusion: Extensive areas of microstructural alteration of the white matter are already present during the first episode of schizophrenia.

Keywords: first episode of schizophrenia, magnetic resonance, diffusion weighted imaging, fractional anisotropy
Grants and funding:

Podpořeno MZ ČR - RVO (FNHK, 00179906), MZ ČR - RVO ("Institut klinické a experimentální medicíny - IKEM, IČ 00023001").

Accepted: December 15, 2018; Published: December 1, 2018  Show citation

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Slezák O, Žižka J, Škoch A, Bayer D, Španiel F, Tintěra J, et al.. Changes of fractional anisotropy of the cerebral white matter in first-episode schizophrenia. Ces radiol. 2018;72(4):268-273. doi: 10.55095/CesRadiol2018/037.
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