Ces radiol. 2020, 74(3):196-201 | DOI: 10.55095/CesRadiol2020/030

dGEMRIC technique in cartilage imaging, comparison of results using contrast media Gd-DTPA2- (Magnevist) and Gd-DOTA- (Dotarem)Original article

Andrea Šprláková-Puková1, Eva Koriťáková2, Alena Štouračová1, Martin Repko3, Petr Vališ3, Tomáš Otaševič3, Jaroslav Tintěra4
1 Klinika radiologie a nukleární medicíny LF MU a FN, Brno
2 Institut biostatistiky a analýz LF MU, Brno
3 Ortopedická klinika LF MU a FN, Brno
4 Základna radiodiagnostiky a intervenční radiologie IKEM, Praha

Aim: The aim of this project is to assess the feasibility Gd-DOTA- (Dotarem) for imaging of hyalinne cartilage using delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) to replace Gd-DTPA2- (Magnevist).

Methods: The project was a part of a study of postoperative cartilage changes. MR examination was performed on a Philips Ingenia 3T using a 8-channels dS knee coil, dGEMRIC 3D IR-GRE sequence with five different inversion times (100, 200, 400, 800 and 1600 ms), voxel: 0.5 × 0.5 × 3 mm3, FOV 160 mm, 40 slices, TR 1800 ms, TE 2 ms, 8 ° flip angle, SENSE factor 2. The baseline examination was performed before surgery (M0), 6 months (M6), 12 (M12) and 18 (M18) months after surgery. Comparisons were made in these groups of patients: 11 patients with Magnevist at initial examination M0 and M6, 8 patients with Magnevist at M0 and Dotarem in M6, and finally 6 patients with Dotarem at M0 and also M6 examination.

Results: The median values of the index change were similar in the Magnevist-Magnevist and Dotarem-Dotarem groups (2.7 and 2.4, respectively, p = 0.961 before correction and 1.000 after correction for multiple comparisons). The median index change in the Magnevist-Dotarem group was higher (4.8) compared to the two other groups, but the difference was not statistically significant (p = 0.351 and p = 0.662 before correction; 1.000 in both cases after correction).

Conclusion: dGEMRIC is feasible using Gd-DOTA- (Dotarem), there was no statistically significant difference (p = 0. 637) between the two types of contrast media.

Keywords: magnetic resonance imaging, contrast agent, hyalinne cartilage
Grants and funding:

Práce byla podpořena MZ ČR - RVO (FNBr, 16-30833A) a MZ ČR - RVO (FNBr, 65269705).

Accepted: August 1, 2020; Published: September 1, 2020  Show citation

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Šprláková-Puková A, Koriťáková E, Štouračová A, Repko M, Vališ P, Otaševič T, Tintěra J. dGEMRIC technique in cartilage imaging, comparison of results using contrast media Gd-DTPA2- (Magnevist) and Gd-DOTA- (Dotarem). Ces radiol. 2020;74(3):196-201. doi: 10.55095/CesRadiol2020/030.
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