Ces radiol. 2022, 76(2):107-113 | DOI: 10.55095/CesRadiol2022/013

Fixel-based analysis in patients after the first episode in schizophreniaOriginal article

Ondřej Slezák1, Antonín Škoch2,3, Jan Žižka4, David Bayer5, Filip Španiel3, Jaroslav Tintěra2, Jiří Vaňásek1, Pavel Eliáš1,6, Pavel Ryška1
1 Radiologická klinika LF UK a FN, Hradec Králové
2 Základna radiodiagnostiky a intervenční radiologie IKEM, Praha
3 Národní ústav duševního zdraví, Klecany
4 Department of Radiology, University Hospital of Umea, Sweden
5 Psychiatrická klinika LF UK a FN, Hradec Králové
6 Ústav radiodiagnostický FN, Ostrava

Purpose: To assess white matter changes after the first episode of schizophrenia by using fixel-based analysis (FBA).

Methods: Diffusion weighted MR images were used to prospectively compare white matter microstructure between subjects after the first episode of schizophrenia (n = 16) and healthy controls (n = 22). The subjects were examined on a 3 Tesla MRI system equipped with a 64-channel head coil. FBA was performed using MRtrix software package (version 3.0.1).

Results: A limited area of fibre density decrease was found in the anterior commissure. No fixels of fibre cross-section changes were found. For combined metric of fibre density and cross-section only one statistically significant fixel was found in the right frontal white matter.

Conclusion: Using FBA, only a limited area of white matter microstructure corruption was found after the first episode of schizophrenia. Changes were located mainly in the anterior commissure. Compared to other published studies using FBA, the extent of changes is distinctly smaller which can be among other causes subjected to earlier stages of the illness of subjects included in this study.

Keywords: diffusion weighted imaging, fixel-based analysis, fractional anisotropy, first episode of schizophrenia, magnetic resonance
Grants and funding:

Podpořeno z programových projektů Ministerstva zdravotnictví ČR s reg. č. NU20-04-00393, NU21-08-00432, RVO (Institut klinické a experimentální medicíny - IKEM, IČ 00023001) a RVO (FNHK, 00179906).

Accepted: March 1, 2022; Published: June 1, 2022  Show citation

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Slezák O, Škoch A, Žižka J, Bayer D, Španiel F, Tintěra J, et al.. Fixel-based analysis in patients after the first episode in schizophrenia. Ces radiol. 2022;76(2):107-113. doi: 10.55095/CesRadiol2022/013.
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